Initial tests have shown excellent reproducibility at high conversion rates, while ensuring a high degree of flexibility and easy to use for the users.

Further information is provided in a whitepaper.

 

For oxygen and moisture sensitive reactions, such as metal-catalytically supported cross-coupling reactions like Heck cross-coupling or  Buchwald-Hartwig amidation, the absence of traces of oxygen is decisive for a good result.

In order to ensure reproducible conversions on a screening scale, an inerting manifold for the XELSIUS parallel synthesis reactor was developed in cooperation with scientists from Boehringer Ingelheim, Biberach.